We are the Laboratory for Mucosal Immunology at ETH Zurich

Our lab is dedicated to understand the interactions between microbes and the host at mucosal surfaces. We are interested in applying this knowledge to prevent and treat human and veterinary diseases. We want to understand how diet, microbiota, metabolism and immunity interact in health and disease. We are excited to announce that the Slack lab will be starting a new group at the William Dunn School of Pathology, University of Oxford from Spring 2023. If you are interested in working with us in the UK, please keep an eye here for links to open positions.

Have a look at our research projects here Research projects
Have a look at our Publications here Publications
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Mucosal immune system

The interactions between diet, the microbiota and the host immune system

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"Next-generation" vaccines

Safe and effective vaccines for application in livestock rearing.

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Microbiota metabolism

Mechanistic understanding of food-as-therapy for microbiota/immunity-related diseases.

Research Projects

Our current understanding of microbiota population dynamics in the gut is based on the sequencing data or the quantification of certain strains by culture.

Publications

Reproducible Colonization of Germ-Free Mice With the Oligo-Mouse-Microbiota in Different Animal Facilities

Claudia Eberl, Diana Ring, Philipp C. Münch, Markus Beutler, Marijana Basic, Emma C. Slack, Martin Schwarzer, Dagmar Srutkova, Anna Lange, Julia S. Frick, André Bleich and Bärbel Stecher

Frontiers in Microbiology, vol. 10, pp. 2999, Lausanne: Fontiers Research Foundation, 2020.

Reproducible Colonization of Germ-Free Mice With the Oligo-Mouse-Microbiota in Different Animal Facilities

Claudia Eberl, Diana Ring, Philipp C. Münch, Markus Beutler, Marijana Basic, Emma C. Slack, Martin Schwarzer, Dagmar Srutkova, Anna Lange, Julia S. Frick, André Bleich and Bärbel Stecher

Frontiers in Microbiology, vol. 10, pp. 2999, Lausanne: Fontiers Research Foundation, 2020.

IgA and the intestinal microbiota: the importance of being specific

Oliver Pabst and Emma Slack

"Mucosal Immunology, vol. 13: no. 1, pp. 12-21, New York, NY: Nature Publishing Group, 2020."

Growing, evolving and sticking in a flowing environment: understanding IgA interactions with bacteria in the gut

Daniel Hoces, Markus Arnoldini, Médéric Diard, Claude Loverdo and Emma Wetter Slack

"Immunology, vol. 159: no. 1, pp. 52-62, Hoboken, NJ: Wiley, 2020."

Meet the team

Alumni

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Dr. Kathrin Moor (PhD Student)

Regulatory Affairs Specialist, University Hospital Zurich

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    Sara Berent (Master Student)

    Business Developer, Angle Audio (Switzerland)

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    Naomi Dünki (Master Student)

    Medical Science Liaison, Novartis (Japan)

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    Claudia Moresi (Research Technician)

    Research Associate, Biognosys (Schlieren)

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    Tobias Geiser (Bachelor Student)

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    Dr. Corina Matthew (Postdoc)

    Postgraduate Felllow in Clinical Development, Novartis (Switzerland)

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    Basak Corak (Master Student)

    PhD Student, Institute of Physiology, University of Zurich

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    Daria Künzli (Master Student)

    Research Assistant, Department of Health Sciences and Technology (Vogel Group)

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    Alicia Halbach (Intern)

    Bachelor Student, University College London

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    Katja Sommer (Intern)

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    Helena Schmitt (Master Student)

    High School Biology Teacher, Lucerne

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    Ioana Domocos (Semester Project Student)

    Master Student, Institute of Experimental Immunology, University of Zurich

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    Elena Melgarejo Ros (Semester Project Student)

    Intern, Institute of Microbiology, ETH Zurich (Hardt Group)

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    Julien Huttman (Semester Project Student)

    Master Student, ETH Zurich

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    Cheickna Diawara (Master Student)

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    Nina Zuber (Intern)

    Medical Student, ETH Zurich

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    Raffael Schumann (Research Assistant)

    Research Assistant, MRC Laboratory of Molecular Biology (Cambridge, England)

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    Lucas Piech (Master Student)

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    Ursina Enz (Semester Project Student)

    Master Student, ETH Zurich

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    Gianna La Regina (Semester Project Student)

    Master Student, ETH Zurich

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    Julien Chabbey (Semester Project Student)

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    Daniel Hoces Burga (PhD Student)

    Postdoctoral Scholar, Department of Bioengineering, Stanford University (USA)

  • Media

    Check out the latest video from the Botnar Research Centre for Child Health (BRCCH) introducing the multi-investigator research project led by Prof Emma Slack, ETH Zurich. Two very serious diseases of newborns – namely, inborn errors of metabolism and neonatal sepsis – currently have high mortality rates, long-term consequences for child development and limited treatment options. The project seeks to develop novel intervention strategies for these diseases using advancements in microbiota bioengineering.

    Botnar Research Centre for Child Health

    Have a look at the video of the BRCCH introducing itself and its mission. It also includes some insights into the different research projects that have received funding in their multi-investigator project call in 2019.

    SRF Puls on vaccine research

    Watch the SRF Puls coverage on our research on Corona virus vaccines.

    Impfung treibt Salmonellen in die Evolutions-Falle

    Schädliche Darmbakterien mutieren und machen uns so das Leben schwer. Doch die Mutationen könnten ihnen auch zum Verhängnis werden.

    A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants

    Intestinal antibodies (IgA) can exert selective pressure on intestinal bacteria. Via oral vaccines, we can manipulate these selective pressures to force evolution of Salmonella that are impaired in transmitting disease. This new vaccination strategy could be used to prevent disease caused by antibiotic-resistant intestinal bacteria.

    NCCR women: Emma Slack, Immunologin

    To celebrate the 50th anniversary of women's right to vote in Switzerland, the NCCR has launched a campagin introducing female researchers in Switzerland.